BackgroundThe Familial Bowel Cancer Service at The Royal Melbourne Hospital was started in 1980 in order to offer bowel cancer screening services to those felt to be at a higher risk of CRC due to their family history, and upon registration in this service, patients gave consent for recording of their individual and familial medical history as pertaining to colorectal cancer in the FamBIS database. Using the FamBIS database, we sought to understand whether the subpopulation of individuals in whom both parents were diagnosed with colorectal cancer carried a higher risk of colorectal cancer or neoplastic polyps and should therefore undergo more intensive screening above that of the average-risk individual.MethodsWe conducted a single-centre retrospective cohort-study of adults (18 years of age and older) in the FamBIS database, with review of their medical histories as pertaining to CRC diagnosis, screening, and surveillance from 1980 to 2015.ResultsWe identified and reviewed the medical histories of 96 registrants from 62 unique families. Registrants began screening as early as 24 years of age, with the mean age of first screening being at 44.6 ± 10.7 years old. The mean duration of screening was 17.3 ± 10.1 years, and through their screening period, registrants underwent an average of 11.5 ± 9.1 FOBTs and 4.4 ± 3.1 colonoscopies or sigmoidoscopies.Over the course of screening, 41 (42.7%) registrants were found to have at least one neoplasm of any kind (including adenomas, advanced adenomas, and CRC) as their first positive colonoscopic finding. In total, 12 (12.5%) of the registrants were found to have an advanced neoplasm over the course of screening and surveillance, while only 2 patients were found to be diagnosed with CRC.ConclusionsThe prevalence rates for neoplasms, advanced neoplasms, and CRC in our current study were statistically significantly higher compared with those seen in average-risk populations. This supports the importance of more intensive screening for this subpopulation in preventing colorectal cancers, as well as pre-and early-cancerous neoplasms.

中文翻译：

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有两个父母受结直肠癌影响的人的筛查和监测结果：来自家族性肠癌服务的经验

背景 皇家墨尔本医院的家族性肠癌服务始于 1980 年，旨在为那些因家族史而被认为具有较高 CRC 风险的人提供肠癌筛查服务，并且在注册该服务后，患者同意在 FamBIS 数据库中记录与结直肠癌有关的个人和家族病史。使用 FamBIS 数据库，我们试图了解父母双方都被诊断患有结直肠癌的个体亚群是否具有更高的结直肠癌或肿瘤性息肉风险，因此是否应该接受比平均风险个体更高的筛查。方法我们在 FamBIS 数据库中对成年人（18 岁及以上）进行了单中心回顾性队列研究，回顾他们从 1980 年到 2015 年与 CRC 诊断、筛查和监测有关的病史。结果我们确定并回顾了来自 62 个独特家庭的 96 名登记者的病史。登记者早在 24 岁时就开始筛查，首次筛查的平均年龄为 44.6 ± 10.7 岁。筛查的平均持续时间为 17.3 ± 10.1 年，在筛查期间，登记者平均接受了 11.5 ± 9.1 次 FOBT 和 4.4 ± 3.1 次结肠镜检查或乙状结肠镜检查。在筛查过程中，发现 41 名 (42.7%) 登记者患有至少一个任何类型的肿瘤（包括腺瘤、晚期腺瘤和 CRC）作为他们的第一个阳性结肠镜检查结果。总共有 12 名（12.5%）的注册者在筛查和监测过程中被发现患有晚期肿瘤，而只有 2 名患者被诊断出患有 CRC。结论在我们目前的研究中，肿瘤、晚期肿瘤和 CRC 的患病率在统计学上显着高于平均风险人群中的患病率。这支持了对该亚群进行更密集筛查在预防结直肠癌以及癌前和早期肿瘤中的重要性。