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Fundamentals of Cellular Calcium Signaling: A Primer.
Cold Spring Harbor Perspectives in Biology ( IF 7.2 ) Pub Date : 2020-01-02 , DOI: 10.1101/cshperspect.a038802
Martin D Bootman 1 , Geert Bultynck 2
Affiliation  

Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular Ca2+ signaling and/or Ca2+ homeostasis can subvert physiological processes into driving pathological outcomes. Imaging of living cells over the past decades has demonstrated that Ca2+ signals encode information in their frequency, kinetics, amplitude, and spatial extent. These parameters alter depending on the type and intensity of stimulation, and cellular context. Moreover, it is evident that different cell types produce widely varying Ca2+ signals, with properties that suit their physiological functions. This primer discusses basic principles and mechanisms underlying cellular Ca2+ signaling and Ca2+ homeostasis. Consequently, we have cited some historical articles in addition to more recent findings. A brief summary of the core features of cellular Ca2+ signaling is provided, with particular focus on Ca2+ stores and Ca2+ transport across cellular membranes, as well as mechanisms by which Ca2+ signals activate downstream effector systems.

中文翻译:

细胞钙信号的基本原理:入门。

离子钙 (Ca2+) 是最通用的细胞信使。所有细胞都使用 Ca2+ 信号来调节它们的活动以响应外在和内在刺激。细胞 Ca2+ 信号传导和/或 Ca2+ 稳态的改变可以颠覆生理过程,从而导致病理结果。过去几十年的活细胞成像表明,Ca2+ 信号在其频率、动力学、振幅和空间范围内编码信息。这些参数根据刺激的类型和强度以及细胞环境而改变。此外,很明显,不同的细胞类型会产生广泛不同的 Ca2+ 信号,具有适合其生理功能的特性。本入门书讨论了细胞 Ca2+ 信号传导和 Ca2+ 稳态的基本原理和机制。最后,除了最近的发现之外,我们还引用了一些历史文章。提供了细胞 Ca2+ 信号核心特征的简要总结,特别关注 Ca2+ 储存和 Ca2+ 跨细胞膜转运,以及 Ca2+ 信号激活下游效应系统的机制。
更新日期:2019-11-01
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