Peripheral nerve injury creates unusual sensitivity and pathological spontaneous activity in neurons that are described as ectopic discharge. Voltage dependent Na channels are responsible for ectopic discharge. Topiramate (TOP) inhibits voltage-gated sodium channels by blocking both the amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kainate receptor and folic acid (FA) activity in neurotransmitter synthesis reactions. FA and TOP are anti-apoptotic agents by both phosphorylated-Akt (p-Akt) signaling activation and anti-inflammatory effects at the injury site. We investigated the effects of FA and TOP in peripheral nerve injury. We used rats with a sciatic nerve injury (SNI) treated with FA or TOP once daily for 6 weeks. Histological and electrophysiological tests were used to evaluate the morphology, and motor and sensory functions. Numbers of axons, myelin sheath thickness and axon area were measured using stereological techniques; functionality also was evaluated. Although FA exhibited a positive effect on regeneration by increasing the number of axons, we found no difference in axonal outgrowth or myelin sheath formation between the TOP and FA groups.

中文翻译：

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叶酸和托吡酯对周围神经再生的影响。

周围神经损伤在神经元中产生异常的敏感性和病理性自发活动，被称为异位放电。电压依赖性Na通道负责异位放电。托吡酯（TOP）通过阻断神经递质合成反应中的氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）/海藻酸酯受体和叶酸（FA）活性来抑制电压门控钠通道。FA和TOP通过磷酸化Akt（p-Akt）信号激活和损伤部位的抗炎作用，具有抗凋亡作用。我们调查了FA和TOP在周围神经损伤中的作用。我们使用每天用FA或TOP处理一次的坐骨神经损伤（SNI）大鼠，持续6周。组织学和电生理学测试用于评估形态，运动和感觉功能。轴突的数量，髓鞘厚度和轴突面积是使用立体技术测量的。功能也进行了评估。尽管FA通过增加轴突的数量显示出对再生的积极作用，但我们发现TOP组和FA组之间的轴突生长或髓鞘形成没有差异。