The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their initial origins to their final destinations and imbue their derivatives with aspects of form including their axial orientation, anatomical identity, size, and shape. Perturbations along the way can produce defects and disease, but also generate the variation necessary for jaw evolution and adaptation. We focus on molecular and cellular mechanisms that regulate form in the amniote jaw complex, and that enable structural and functional integration. Special emphasis is placed on the role of cranial neural crest mesenchyme (NCM) during the species-specific patterning of bone, cartilage, tendon, muscle, and other jaw tissues. We also address the effects of biomechanical forces during jaw development and discuss ways in which certain molecular and cellular responses add adaptive and evolutionary plasticity to jaw morphology. Overall, we highlight how variation in molecular and cellular programs can promote the phenomenal diversity and functional morphology achieved during amniote jaw evolution or lead to the range of jaw defects and disease that affect the human condition.

中文翻译：

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羊膜颚骨形式和功能进化的分子和细胞机制。

羊膜颚复合体是来自不同胚胎细胞谱系的衍生物的显着合并。在发育过程中，这些谱系中的细胞经历协调一致的运动，迁移和信号传导相互作用，使它们从最初的起源转移到最终的目的地，并使它们的衍生物充满形式方面，包括轴向，解剖学特征，大小和形状。沿途的摄动会产生缺陷和疾病，但也会产生颌部进化和适应所必需的变化。我们专注于调节羊膜颚复合体形式的分子和细胞机制，并使结构和功能整合成为可能。特别强调颅神经neural间充质（NCM）在骨骼，软骨，肌腱，肌肉，和其他颌骨组织。我们还解决了颌骨发育过程中生物力学作用的影响，并讨论了某些分子和细胞反应为颌骨形态增加适应性和进化可塑性的方式。总的来说，我们强调分子和细胞程序的变化如何促进羊膜颌骨进化过程中实现的惊人多样性和功能形态，或导致影响人类状况的颌骨缺损和疾病范围。