The anterior cingulate cortex (ACC), surrounding the genu of the corpus callosum, plays important roles in emotional processing and is functionally divided into the dorsal, perigenual, and subgenual subregions (dACC, pgACC, and sgACC, respectively). Previous studies have suggested that the pgACC and sgACC have distinctive roles in the regulation of emotion. In order to elicit appropriate emotional responses, these ACC regions require sensory information from the environment. Anatomically, the ACC has rich connections with the temporal lobe, where the higher-order processing of sensory information takes place. To clarify the organization of sensory inputs into the ACC subregions, we injected neuronal tracers into the pgACC, sgACC, and dACC and compared the afferent connections. Previously, we analyzed the afferent projections from the amygdala and found a distinct pattern for the sgACC. In the present study, the patterns of the afferent projections were analyzed in the temporal cortex, especially the temporal pole (TP) and medial temporal areas. After tracers were injected into the sgACC, we observed labeled neurons in the TP and the subiculum of the hippocampal formation. The majority of the labeled cell bodies were found in the superficial layers of the TP ("feedforward" type projections). The pgACC received afferent projections from the TP, the entorhinal cortex (EC), and the parahippocampal cortex (PHC), but not from the hippocampus. In each area, the labeled cells were mainly found in the deep layers ("feedback" type projection). The pattern for the dACC was similar to that for the pgACC. Previous studies suggested that the pgACC, but not the sgACC receive projections from the dorsolateral prefrontal cortex (DLPFC). These data suggest that the sgACC plays crucial roles for emotional responses based on sensory and mnemonic inputs from the anterior temporal lobe, whereas the pgACC is more related to the cognitive control of emotion.

中文翻译：

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投影的层流模式表示前扣带-颞叶情感系统的层次组织。

围绕call体属的前扣带回皮层（ACC）在情绪加工中起重要作用，并在功能上分为背，周和次亚区域（分别为dACC，pgACC和sgACC）。先前的研究表明，pgACC和sgACC在情绪调节中具有独特的作用。为了引起适当的情绪反应，这些ACC区域需要来自环境的感官信息。从解剖学上讲，ACC与颞叶有着丰富的联系，在颞叶进行感觉信息的高阶处理。为了弄清进入ACC子区域的感觉输入的组织，我们将神经元示踪剂注入pgACC，sgACC和dACC，并比较传入连接。先前，我们分析了杏仁核的传入预测，并发现了sgACC的独特模式。在本研究中，分析了颞皮质中传入投影的模式，尤其是颞极（TP）和颞内侧区域。将示踪剂注射到sgACC中后，我们在TP和海马结构的亚支下观察到标记的神经元。在TP的表层（“前馈”型投影）中发现了大多数标记的细胞体。pgACC从TP，内嗅皮层（EC）和海马旁皮层（PHC）接收到传入的投影，但从海马没有得到。在每个区域中，标记的细胞主要位于深层（“反馈”型投影）。dACC的模式与pgACC的模式相似。先前的研究表明pgACC而不是sgACC从背外侧前额叶皮层（DLPFC）接收投影。这些数据表明，sgACC在基于来自前颞叶的感觉和记忆输入的情绪反应中起着至关重要的作用，而pgACC与情绪的认知控制更为相关。