Triple Negative Breast Cancers (TNBC) are heterogeneous and aggressive pathologies, with distinct morphological and clinical characteristics associated with their genetic diversity, epigenetics, transcriptional changes and aberrant molecular patterns. Treatment with anti-neoplastic drugs exerts systemic effects with low specificity, and incipient improvement in overall survival due to chemoresistance and recurrence. New alternatives for TNBC treatment are urgent and parthenolide or its analogues have been explored. Parthenolide is a sesquiterpene lactone with promising antitumor effects against TNBC cell lines. This review highlights the importance of parthenolide and its analogue drugs in TNBC treatment.

三阴性乳腺癌（TNBC）是异质性和侵袭性病理，具有与它们的遗传多样性，表观遗传学，转录变化和异常分子模式相关的独特形态和临床特征。用抗肿瘤药物治疗会产生全身性效应，但特异性较低，并且由于化学抗药性和复发性，总体生存率会得到初步改善。TNBC治疗的新替代品迫在眉睫，并且已经研究了单苯乙内酯或其类似物。偏苯二酚是倍半萜内酯，对TNBC细胞系具有良好的抗肿瘤作用。这篇综述强调了单烯酚及其类似药物在TNBC治疗中的重要性。