It is well known that the amount and type of ingested fat impacts the development of obesity and metabolic diseases, but the potential for beneficial effects from fat has received less attention. It is becoming clear that the composition of the individual fatty acids in diet is important. Besides acting as precursors of potent signaling molecules, dietary fatty acids act directly on intracellular and cell surface receptors. The free fatty acid receptor 4 (FFA4, previously GPR120) is linked to the regulation of body weight, inflammation, and insulin resistance and represents a potential target for the treatment of metabolic disorders, including type 2 diabetes and obesity. In this review, we discuss the various types of dietary fatty acids, the link between FFA4 and metabolic diseases, the potential effects of the individual fatty acids on health, and the ability of fatty acids to activate FFA4. We also discuss the possibility of dietary schemes that implement activation of FFA4.

中文翻译：

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膳食脂肪酸及其通过活化FFA4 / GPR120控制代谢性疾病的潜力。

众所周知，摄入的脂肪的数量和类型会影响肥胖症和代谢性疾病的发展，但是脂肪产生有益作用的可能性却很少受到关注。显然，饮食中各个脂肪酸的组成很重要。膳食脂肪酸除了充当有效信号分子的前体外，还直接作用于细胞内和细胞表面受体。游离脂肪酸受体4（FFA4，以前称为GPR120）与体重，炎症和胰岛素抵抗的调节有关，是治疗代谢性疾病（包括2型糖尿病和肥胖症）的潜在靶标。在这篇评论中，我们讨论了各种类型的饮食脂肪酸，FFA4与代谢疾病之间的联系，单个脂肪酸对健康的潜在影响，以及脂肪酸激活FFA4的能力。我们还将讨论实现FFA4激活的饮食计划的可能性。