Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.

中文翻译：

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白细胞介素28A促进白塞病患者外周血单个核细胞产生IFN-γ。

白塞氏病（BD）是一种病因不明的自身免疫性疾病。白介素28A（IL-28A）促进免疫反应，并可能参与自身免疫性疾病的发病机理。为了检查IL-28A在BD发病机理中的作用，我们通过IL-28A刺激的19例BD患者和16例健康个体的外周血单个核细胞（PBMC）测量了IFN-γ和IL-17的表达。我们发现在BD患者和对照组的血清中无法检测到IFN-γ和IL-17。与健康个体相比，来自BD患者的IL-28A刺激的PBMC的IFN-γ的mRNA表达和蛋白质产生显着增加。在BD患者和正常人之间，IL-28A刺激的PBMC在IL-17的mRNA表达和蛋白质产生中未观察到显着差异。