Interferon lambda-1 (IFN-lambda1), the prototype Type-III interferon, has antiviral functions similar to those of the Type-I interferons, IFN-alpha and IFN-beta. However, IFN-lambda1 is capable of signaling through almost all STAT molecules and so it is possible that it may have novel immunoregulatory functions in addition to antiviral ones. From a range of chemokines tested, IFN-lambda1 elevated mRNA levels of only 'Monokine induced by IFN-gamma' (MIG/CXCL9), 'IFN-gamma inducible protein-10' (IP-10/CXCL10) and 'IFN-gamma inducible T-cell alpha chemoattractant' (I-TAC/CXCL11) from human peripheral blood mononuclear cells. As their names suggest, these chemokines are also induced by IFN-gamma, the only member of the Type-II interferon family. This action of IFN-lambda1 did not depend on intermediate induction of IFN-gamma and is therefore, likely to be independent of IFN-gamma. Further, our results suggest that donors responded to IFN-lambda1 stimulation either 'early' or 'late'. Overall the action of IFN-lambda1 was similar to that previously reported for IFN-gamma and may invite more detailed investigation of the role of IFN-lambda1 at the innate/adaptive interface.

中文翻译：

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干扰素lambda-1（IFN-lambda1 / IL-29）以IFN-γ独立的方式诱导人外周血单个核细胞中的ELR（-）CXC趋化因子mRNA。

干扰素lambda-1（IFN-lambda1），III型干扰素的原型，具有与I型干扰素，IFN-α和IFN-β相似的抗病毒功能。但是，IFN-lambda1几乎可以通过所有STAT分子进行信号传导，因此除抗病毒功能外，它还可能具有新型的免疫调节功能。在一系列测试的趋化因子中，IFN-lambda1仅提高了“IFN-γ诱导的单核因子”（MIG / CXCL9），“IFN-γ诱导蛋白10”（IP-10 / CXCL10）和“IFN-γ”的mRNA水平。人外周血单核细胞诱导性T细胞α趋化因子（I-TAC / CXCL11）。顾名思义，这些趋化因子也是由IFN-γ（II型干扰素家族的唯一成员）诱导的。IFN-lambda1的这种作用不依赖于IFN-γ的中间诱导，因此很可能独立于IFN-γ。此外，我们的结果表明供体对IFN-lambda1刺激的反应“较早”或“较晚”。总体而言，IFN-lambda1的作用与先前报道的IFN-γ相似，可能会引起对IFN-lambda1在先天/适应界面的作用的更详细研究。