The cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival and recovery. Posttranscriptional regulatory events are considered as critical mechanisms that modulate core characteristics of mRNA transcripts to promote cell adaptation to various assaults. While the impact of processes such as mRNA splicing, turnover, localization, and translation on the cellular stress response has been extensively studied, recent observations highlight the role of alternative polyadenylation (APA) in response to challenges such as oxidative stress, heat shock, and starvation. The role of APA is comprehensive with far reaching effects on mRNA stability, mRNA localization, and protein coding sequences. Nonetheless, APA remains a relatively unappreciated mode of gene regulation despite its role in regulating key mediators of the stress response. The goal of this review is to provide an overview of the recent advances in our understanding of the various ways by which APA affects cell adaptation to its environment and discuss how a defect in APA could have deleterious consequences on cell survival. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA Processing > 3' End Processing.

中文翻译：

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替代的聚腺苷酸化和应激反应。

细胞应激反应是所有生物生存所必需的普遍机制。这个多方面的过程主要是由基因表达的调节所驱动，以产生适合于促进细胞存活和恢复的细胞内环境。转录后调控事件被认为是调节mRNA转录本核心特征以促进细胞适应各种攻击的关键机制。尽管已经广泛研究了诸如mRNA剪接，周转，定位和翻译等过程对细胞应激反应的影响，但最近的观察结果突出了替代性聚腺苷酸化（APA）在应对诸如氧化应激，热休克和氧化应激等挑战中的作用。饥饿。APA的作用全面，对mRNA稳定性，mRNA定位，和蛋白质编码序列。尽管如此，尽管APA在调节压力反应的关键介体中起着作用，但它仍然是一种相对不为人知的基因调节方式。这篇综述的目的是概述我们对APA影响细胞适应其环境的各种方式的最新进展，并讨论APA缺陷如何对细胞存活产生有害影响。本文归类于：疾病与发展中的RNA>疾病中的RNA RNA结构与动力学> RNA结构在生物系统中的影响RNA加工> 3'末端加工。这篇综述的目的是概述我们对APA影响细胞适应其环境的各种方式的最新进展，并讨论APA缺陷如何对细胞存活产生有害影响。本文归类于：疾病与发展中的RNA>疾病中的RNA RNA结构与动力学> RNA结构在生物系统中的影响RNA加工> 3'末端加工。这篇综述的目的是概述我们对APA影响细胞适应其环境的各种方式的最新进展，并讨论APA缺陷如何对细胞存活产生有害影响。本文归类于：疾病与发展中的RNA>疾病中的RNA RNA结构与动力学> RNA结构在生物系统中的影响RNA加工> 3'末端加工。