BACKGROUND Anxiety and depression have been associated with an increased perception of gastroesophageal reflux symptoms, but there is a paucity of data regarding the outcomes of laparoscopic Nissen Fundoplication (LNF) in this patient population. METHODS We performed a retrospective cohort study including all patients undergoing LNF between 2011 and 2017. Patients were stratified by baseline usage of serotonin-modulating medication or benzodiazepines as a proxy for depression and anxiety, respectively. Outcome measures included postoperative gastroesophageal health-related quality of life (GERD-HRQL) scores and overall satisfaction rates after surgery. A p value of < 0.05 was considered statistically significant. RESULTS The population consisted of 271 patients of which 103 patients had depression and 44 patients had anxiety. Patients with depression reported no significant difference in pre- or postoperative GERD-HRQL scores compared to patients without depression and long-term satisfaction rates after surgery were similar in both groups at 76% vs 71%, respectively (p = 0.55). Patients with anxiety reported higher baseline HRQL scores (34 vs. 29, p = 0.05). At long-term follow-up (15 months), patients with anxiety reported slightly worse HRQL scores compared to controls (7 vs. 4, p = 0.11) despite no difference in usage of anti-acid medications or need for endoscopic dilations between the two groups. Patients with anxiety were less likely to report being "satisfied" after surgery (40% vs. 71%, p = 0.01) compared to controls. CONCLUSION Patients with anxiety have higher subjective reporting of GERD symptoms and are more likely to report being "satisfied" during long-term follow-up after LNF. Patients on medication for depression appear to have similar reporting of GERD symptoms and derive as much benefit from LNF as patients that are not. While LNF does improve the symptom burden in patients with anxiety, satisfaction is rarely achieved in long-term follow-up.

中文翻译：

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精神疾病对尼森胃底折叠术后患者满意度的影响。

背景 焦虑和抑郁与对胃食管反流症状的感知增加有关，但关于腹腔镜尼森胃底折叠术 (LNF) 在该患者群体中的结果的数据很少。方法 我们进行了一项回顾性队列研究，纳入了 2011 年至 2017 年间所有接受 LNF 的患者。患者根据基线使用血清素调节药物或苯二氮卓类药物分别作为抑郁和焦虑的代表进行分层。结果指标包括术后胃食管健康相关生活质量（GERD-HRQL）评分和术后总体满意度。p 值 < 0.05 被认为具有统计学意义。结果该人群由271名患者组成，其中103名患者患有抑郁症，44名患者患有焦虑症。与无抑郁症患者相比，抑郁症患者报告的术前或术后 GERD-HRQL 评分无显着差异，两组术后长期满意度相似，分别为 76% 和 71%（p = 0.55）。焦虑患者报告的基线 HRQL 评分较高（34 对 29，p = 0.05）。在长期随访（15 个月）中，尽管在抗酸药物的使用或需要内镜扩张之间没有差异，但与对照组相比，焦虑患者的 HRQL 评分略差（7 对 4，p = 0.11）。两组。与对照组相比，焦虑患者不太可能在手术后报告“满意”（40% 对 71%，p = 0.01）。结论 焦虑患者对 GERD 症状的主观报告程度更高，更有可能报告“