Millions of people every year develop scars in response to skin injuries after surgery, trauma, or burns with significant undesired physical and psychological effects. This review provides an update on engineering strategies for scar-free wound healing and discusses the role of different cell types, growth factors, cytokines, and extracellular components in regenerative wound healing. The use of pro-regenerative matrices combined with engineered cells with less intrinsic potential for fibrogenesis is a promising strategy for achieving scar-free skin tissue regeneration.

中文翻译：

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再生无疤皮肤伤口愈合。

每年有数百万人因手术，外伤或烧伤后的皮肤受伤而产生疤痕，对身体和心理产生重大不良影响。这篇综述提供了无疤痕伤口愈合的工程策略的更新，并讨论了不同细胞类型，生长因子，细胞因子和细胞外成分在再生伤口愈合中的作用。将促再生基质与工程化细胞结合使用，具有较少的内在纤维生成潜力，这是实现无疤痕皮肤组织再生的一种有前途的策略。