Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure quality control of the transcriptome. Many improperly processed transcripts are not exported from the nucleus, are restricted to the site of transcription, and are in some cases degraded, which helps to limit any possibility of aberrant RNA causing harm to cellular health. These critical quality control pathways are regulated by the highly dynamic protein-protein interaction network at the site of transcription. Recent work has further revealed the extent to which the processes of transcription and RNA processing and quality control are integrated, and how critically their coupling relies upon the dynamic protein interactions that take place co-transcriptionally. This review focuses specifically on the intricate balance between 3' end processing and RNA decay during transcription termination. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Processing > 3' End Processing RNA Processing > Splicing Mechanisms RNA Processing > Capping and 5' End Modifications.

中文翻译：

---

写错：耦合的RNA聚合酶II转录和RNA质量控制。

前体RNA种类的加工和成熟与RNA聚合酶II转录偶联。共转录RNA加工有助于确保对不同RNA物种进行有效且适当的加帽，剪接和3'末端加工，从而有助于确保转录组的质量控制。许多处理不当的转录本不会从细胞核中输出，被限制在转录位点，并且在某些情况下被降解，这有助于限制任何异常RNA损害细胞健康的可能性。这些关键的质量控制途径由转录位点的高度动态的蛋白质-蛋白质相互作用网络调节。最近的工作进一步揭示了转录，RNA处理和质量控制的整合程度，以及它们的耦合如何关键取决于共转录过程中发生的动态蛋白质相互作用。这篇综述专门针对转录终止过程中3'末端加工与RNA衰减之间的复杂平衡。本文归类于：RNA转换和监视>转换/监视机制RNA加工> 3'末端加工RNA加工>剪接机制RNA加工>上限和5'末端修饰。