This review describes developments in epilepsy research during the last 3 to 4 decades that focused on the dentate gyrus (DG) and its role in temporal lobe epilepsy (TLE). The emphasis is on basic research in laboratory animals and is chronological, starting with hypotheses that attracted a lot of attention in the 1980s. Then experiments are described that addressed the questions, as well as new methods that often made the experiments possible. In addition, where new questions arose and the implications for clinical epilepsy are discussed.

中文翻译：

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齿状回和颞叶癫痫：一个“激动人心”的时代。

这篇综述描述了过去 3 到 4 年间癫痫研究的进展，重点关注齿状回 (DG) 及其在颞叶癫痫 (TLE) 中的作用。重点是实验动物的基础研究，并且是按时间顺序进行的，从 20 世纪 80 年代引起广泛关注的假设开始。然后描述了解决这些问题的实验，以及通常使实验成为可能的新方法。此外，还讨论了出现的新问题及其对临床癫痫的影响。