Hippocampal Contributions to Model-Based Planning and Spatial Memory. Vikbladh OM, Meager MR, King J, et al. Neuron. 2019;102:1-11. pii: S0896-6273(19)30123-0. doi: 10.1016/j.neuron.2019.02.014. [Epub ahead of print] PMID: 30871859 Little is known about the neural mechanisms that allow humans and animals to plan actions using knowledge of task contingencies. Emerging theories hypothesize that it involves the same hippocampal mechanisms that support self-localization and memory for locations. Yet limited direct evidence supports the link between planning and the hippocampal place map. We addressed this by investigating model-based planning and place memory in healthy controls and patients with epilepsy treated using unilateral anterior temporal lobectomy with hippocampal resection. Both functions were impaired in the patient group. Specifically, the planning impairment was related to right hippocampal lesion size, controlling for overall lesion size. Furthermore, although planning and boundary-driven place memory covaried in the control group, this relationship was attenuated in patients, consistent with both functions relying on the same structure in the healthy brain. These findings clarify both the neural mechanism of model-based planning and the scope of hippocampal contributions to behavior.

中文翻译：

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癫痫病再次发生：癫痫手术后患者研究了基于记忆和模型的计划。

海马对基于模型的计划和空间记忆的贡献。Vikbladh OM，Meager MR，King J等。神经元。2019; 102：1-11。pii：S0896-6273（19）30123-0。doi：10.1016 / j.neuron.2019.02.014。[Epub印刷前] PMID：30871859关于神经机制的知识鲜为人知，该机制使人类和动物能够利用任务偶发事件的知识来计划行动。新兴理论假设，它涉及支持自我定位和位置记忆的海马机制。然而，有限的直接证据支持了规划与海马场所地图之间的联系。我们通过研究基于模型的计划和在健康对照以及使用单侧前颞叶切除术和海马切除术治疗的癫痫患者中的位置记忆来解决此问题。患者组中的两种功能均受损。特别，计划损伤与右海马病变大小有关，控制了整体病变大小。此外，尽管对照组中的规划和边界驱动的位置记忆是共变的，但这种关系在患者中减弱了，这与依赖于健康大脑中相同结构的两种功能是一致的。这些发现阐明了基于模型的计划的神经机制和海马行为的贡献范围。