Objective. Previous neuroimaging studies have described altered activity in brain areas associated with reward processing following reward or punishment. This study examines the extent to which feedback-based experience of gain and loss is associated with electrophysiological correlates. Methods. Twenty-nine healthy participants used a gambling task that focused on actual nonpredictable gains and losses. During the task, an electroencephalography recording was performed in order to assess reward processing. Event-related potentials were analyzed when participants were receiving gain/loss feedback. Results. Event-related potentials revealed higher feedback-related negativity for both overall gain and loss compared with a neutral condition in fronto-centro-parietal electrodes. P3 potentials were significantly increased for high gains/losses compared to neutral and small gains/losses. Conclusion. These results indicate that the paradigm is suitable to evoke specific patterns of reward-related electrophysiological responses. The wavelet analysis showed that electroencephalography frequency variations depended on the amount of gains/losses. Significance. This gambling paradigm is appropriate to measure aspects of feedback processing and could help analyze disease-specific alterations of the reward system in patients.

中文翻译：

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事件相关的可能性与意外的得失有关：使用赌博范式

客观的。先前的神经影像学研究描述了与奖励或惩罚后的奖励处理相关的大脑区域的活动改变。这项研究检查了基于反馈的得失体验与电生理相关性的程度。方法。29 名健康参与者使用赌博任务，专注于实际不可预测的收益和损失。在任务期间，进行了脑电图记录以评估奖励处理。当参与者收到增益/损失反馈时，对事件相关电位进行了分析。结果。与额-中心-顶叶电极中的中性条件相比，事件相关电位显示出更高的整体增益和损失的反馈相关负性。与中性和小收益/损失相比，高收益/损失的 P3 潜力显着增加。结论。这些结果表明该范式适合唤起与奖励相关的电生理反应的特定模式。小波分析表明，脑电图频率的变化取决于增益/损失的数量。意义。这种赌博范式适用于衡量反馈处理的各个方面，并有助于分析患者奖励系统的疾病特异性改变。