Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess their clinical significance in autoimmune disease, such as multiple sclerosis (MS), a chronic progressive demyelinating disease of autoimmune nature. The dysregulated immunity noted in MS features a profound shift from Tregs dominance to Th17 cell superiority. In this review, we discuss the immunobiological basis of statins, their role in autoimmunity related to MS, and the data from experimental models and human studies on their effect on Th17 cells.

中文翻译：

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他汀类药物在多发性硬化中的免疫调节作用：对Th17细胞的影响。

他汀类药物是降低胆固醇的药物，还具有免疫调节特性，尤其影响T细胞的活化和分化，抗原呈递以及调节性T细胞（Tregs）的维持和分化。它们对自体攻击的影响已导致研究人员评估其在自身免疫性疾病（例如多发性硬化症（MS））中的临床意义，该疾病是一种自身免疫性的慢性进行性脱髓鞘疾病。MS中提到的免疫功能失调从Tregs优势向Th17细胞优势转变。在这篇综述中，我们讨论了他汀类药物的免疫生物学基础，他汀类药物在与MS相关的自身免疫中的作用，以及来自实验模型和人体研究的数据对他汀类药物对Th17细胞的影响。