Networks of amyloid-like nanofibrils assembled from short peptide sequences have the ability to form scaffolds that can encapsulate clinically relevant stem cells encouraging their attachment, growth, and differentiation into various lineages which can be used in tissue engineering applications to treat a range of diseases and traumas. In this review, the author highlights a selection of important proof-of-principle papers that show how this class of self-assembled networks is highly suited to biomaterial scaffold development. The author highlights recent studies which have shown that these scaffolds can be used to promote cell and tissue regeneration both in vitro and in vivo. The author also presents some fundamental knowledge gaps which are preventing the widespread translation of such scaffolds. Finally, the author outlines a selection of studies that elucidate molecular assembly mechanisms and biophysical properties of amyloid-like peptide nanofibrils and suggests how studies like these might lead to the ability to generate nanofibril scaffolds with bespoke properties for tissue engineering.

中文翻译：

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淀粉样蛋白样肽纳米纤维作为组织工程的支架：进展和挑战（综述）。

由短肽序列组装而成的淀粉样蛋白样纳米纤维网络具有形成支架的能力，该支架可以封装临床上相关的干细胞，从而促进它们的附着，生长和分化成各种谱系，可用于组织工程应用中，以治疗多种疾病和创伤。在这篇综述中，作者重点介绍了一些重要的原理证明论文，这些论文显示了这类自组装网络如何高度适合生物材料支架的开发。作者重点介绍了最近的研究，这些研究表明这些支架可用于在体外和体内促进细胞和组织的再生。作者还提出了一些基本的知识鸿沟，这些鸿沟阻碍了此类支架的广泛翻译。最后，