AIM To explore the impact of cognitive impairment poststroke on outcomes at 5 years. METHODS Five-year follow-up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) prospective cohort. Two hundred twenty-six ischemic stroke survivors completed Montreal Cognitive Assessments at 6 months poststroke. Outcomes at 5 years included independence in activities of daily living, receipt of informal care, quality of life, and depressive symptoms. Data were analyzed using logistic and linear regression models. Adjusted odds ratios (ORs; 95% confidence interval [CI]) and β coefficients (95% CI) are reported. RESULTS One hundred one stroke survivors were followed up at 5 years. Cognitive impairment at 6 months was independently associated with worse quality of life (B [95% CI]: -0.595 [-0.943 to -0.248]), lower levels of independence (B [95% CI]: -3.605 [-5.705 to -1.505]), increased likelihood of receiving informal care (OR [95% CI]: 6.41 [1.50-27.32]), and increased likelihood of depressive symptoms (OR [95% CI]: 4.60 [1.22-17.40]). Conclusion: Cognitive impairment poststroke is associated with a range of worse outcomes. More effective interventions are needed to improve outcomes for this vulnerable group of patients.

中文翻译：

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认知障碍对中风后结局的影响：五年随访。

目的探讨中风后认知障碍对5年结局的影响。方法对中风二级预防干预和康复行动（ASPIRE-S）的前瞻性队列研究进行了五年随访。226名缺血性中风幸存者在中风后6个月完成了蒙特利尔认知评估。5年后的结果包括独立从事日常生活活动，获得非正式护理，生活质量和抑郁症状。使用逻辑和线性回归模型分析数据。报告了调整后的优势比（OR； 95％置信区间[CI]）和β系数（95％CI）。结果在5年后对101名中风幸存者进行了随访。6个月时的认知障碍与生活质量较差独立相关（B [95％CI]：-0.595 [-0.943至-0.248]），较低的独立性（B [95％CI]：-3.605 [-5.705至-1.505]），接受非正式护理的可能性增加（OR [95％CI]：6.41 [1.50-27.32]）和抑郁症的可能性增加症状（或[95％CI]：4.60 [1.22-17.40]）。结论：中风后认知障碍与一系列较差的预后相关。需要更有效的干预措施来改善这一弱势患者群体的预后。