We performed this study to better elucidate the correlations between vascular endothelial growth factor (VEGF) gene polymorphisms and congenital heart diseases (CHD). Eligible articles were searched in PubMed, Medline, Embase and CNKI. Eighteen studies were finally included in our meta-analysis. A significant association with the risk of CHD was detected for the rs1570360 polymorphism in additive comparison in overall analyses. Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models. In conclusion, our findings indicated that rs1570360 and rs833061 polymorphisms may affect the risk of CHD. In addition, the rs3025039 polymorphism may serve as a genetic biomarker of TOF.

我们进行这项研究是为了更好地阐明血管内皮生长因子（VEGF）之间的相关性。）基因多态性与先天性心脏病（CHD）。在PubMed，Medline，Embase和CNKI中搜索了符合条件的文章。我们的荟萃分析最终包括18项研究。rs1570360多态性在总体分析中的加法比较中检测到与冠心病风险显着相关。根据研究参与者的种族和疾病类型进一步进行亚组分析，结果表明，在加成遗传模型下，rs833061多态性与亚洲人冠心病的风险显着相关，而rs3025039多态性与法洛四联症（TOF）的风险显着相关在显性，隐性和等位基因模型中。总之，我们的发现表明rs1570360和rs833061多态性可能影响冠心病的风险。此外，