Dysregulated expression of neuro-immune markers has previously been linked to HIV-associated neurocognitive impairment. We undertook an exploratory approach in a HIV clade-C cohort, investigating the association between eight immune markers and neurocognitive performance in 99 HIV+ and 51 HIV- participants. Markers were selected on preliminary and putative evidence of their link to key neuro-immune functions. Cognitive performance was established using a battery of tests sensitive to HIV-associated neurocognitive impairment, with domain-based scores utilized in analysis. The markers Thymidine phosphorylase (TYMP) and Neutrophil gelatinase-associated lipocalin (NGAL) were significantly higher while Matrix Metalloproteinase (MMP)9 was significantly lower in HIV+ participants. Our results further showed that in the HIV+ group, worse psychomotor processing speed was associated with higher TYMP and NGAL levels and worse motor function was associated with higher NGAL levels. Future studies should explore the underlying mechanisms of these markers in HIV-associated neurocognitive impairment.

The association of peripheral immune markers with neurocognitive performance in South African HIV-positive patients.

中文翻译：

---

南非HIV阳性患者的免疫标记物与认知能力的关联。

神经免疫标记的表达失调以前已与艾滋病毒相关的神经认知障碍有关。我们在一个HIV进化枝C队列中进行了探索性研究，调查了99个HIV +和51个HIV参与者中8种免疫标记与神经认知功能之间的关联。根据标志物与关键的神经免疫功能的联系的初步和推定证据选择标志物。使用一系列对HIV相关的神经认知障碍敏感的测试来建立认知表现，并在分析中使用基于领域的评分。在HIV +参与者中，标志物胸苷磷酸化酶（TYMP）和中性粒细胞明胶酶相关的脂蛋白（NGAL）显着升高，而基质金属蛋白酶（MMP）9显着降低。我们的结果进一步表明，在HIV +组中，较差的心理运动处理速度与较高的TYMP和NGAL水平相关，而较差的运动功能与较高的NGAL水平相关。未来的研究应探讨这些标记物与HIV相关的神经认知障碍的潜在机制。

南非HIV阳性患者外周免疫标记物与神经认知功能的关系。