Purpose

To apply intracranial vessel wall imaging (VWI) to determine changes in vessel wall characteristics between North American moyamoya patients and controls, as well as with standard clinical measures of moyamoya disease severity.

Methods

North American moyamoya patients and controls underwent intracranial 3.0 T VWI. Moyamoya patients also underwent digital subtraction angiography (DSA), from which modified Suzuki scores (mSS) were calculated. Lumen and outer vessel wall diameters of the supraclinoid internal carotid arteries (ICAs) and basilar artery on VWI were measured by two readers from which wall thickness was calculated. Controls and moyamoya patients were compared in logistic regression using disease category (moyamoya or none) as the dependent variable and wall thickness, age, gender, and side as the explanatory variables (significance: two-sided p < 0.05). In moyamoya patients, regression was performed with mSS as the dependent variable and wall thickness, age, gender, and side as the explanatory variables. Analyses were repeated for each lumen diameter and outer vessel wall diameter in place of wall thickness.

Results

Patients with moyamoya (n = 23, gender = 3/20 male/female; age = 43 ± 12 years) and controls (n = 23, gender = 3/20 male/female, age = 43 ± 13 years) were included. Moyamoya patients showed a significantly smaller ICA lumen and outer vessel wall diameter compared to controls (p < 0.05) but no significant change in vessel wall thickness. Similarly, ICA lumen and outer vessel wall diameters decreased with increasing mSS (p < 0.05).

Conclusion

Findings suggest decreased ICA lumen and outer vessel wall diameters, but no significant difference in wall thickness, between patients and controls. Lumen and outer vessel wall diameters also decreased with disease severity.

中文翻译：

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北美烟雾病患者的血管壁和管腔特征。

目的

要应用颅内血管壁成像（VWI）来确定北美烟雾病患者与对照之间血管壁特征的变化，以及烟雾病严重程度的标准临床指标。

方法

北美烟雾病患者和对照组接受了颅内3.0 T VWI。Moyamoya患者还接受了数字减影血管造影（DSA），从而计算出了修正的Suzuki得分（mSS）。通过两个读数器测量VWI上的蛛网膜上颈内动脉（ICAs）和基底动脉的管腔和血管外壁直径，由此计算壁厚。双面：控制和烟雾患者logistic回归使用疾病类别（烟雾或无）作为因变量和壁厚，年龄，性别，和侧作为解释变量（显着性进行了比较p <0.05）。在烟雾病患者中，以mSS为因变量，以壁厚，年龄，性别和侧面为解释变量进行回归。对每个管腔直径和外部血管壁直径代替壁厚重复进行分析。

结果

包括烟雾病患者（n  = 23，性别= 3/20男性/女性；年龄= 43±12岁）和对照组（n  = 23，性别= 3/20男性/女性，年龄= 43±13岁）。Moyamoya患者的ICA管腔和血管外壁直径明显小于对照组（p  <0.05），但血管壁厚度无明显变化。同样，ICA管腔和血管外壁直径随mSS的增加而减小（p  <0.05）。

结论

研究结果表明，患者和对照组之间的ICA腔和外血管壁直径均减小，但壁厚无明显差异。管腔和血管外壁的直径也随着疾病的严重程度而降低。