Organogenesis ( IF 2.3 ) Pub Date : 2019-07-22 , DOI: 10.1080/15476278.2019.1633168 Sonam Patel 1 , Isha Ranadive 1 , Isha Desai 2 , Suresh Balakrishnan 1
Studies using fish fin as a model to understand the nuance of epimorphosis are gaining interest of lately. This study illustrates for the first time the daily changes in the tissue architecture of regenerating tail fin of Poecilia latipinna. Wound epithelium is formed within 24 hpa that eventually gets stratified into apical epithelial cap by 48 hpa. In the subsequent day, proliferating cells accumulate in front of each fin-ray marking the beginning of blastema. Distally these cells express signs of cartilage condensation by 4 dpa. However, ossification and subsequent transformation of actinotrichia to lepidotrichia was observed on 5 dpa. Subsequently, the regenerate grew at variable rate until it achieved the original size on 25 dpa. This result would serve as a worthwhile standard reference for further explorative studies that demand manipulation of a regulatory signal at a defined time point.
中文翻译:
Poecilia latipinna尾鳍的再生:进行性组织形态发生的见解。
最近,以鱼翅为模型来了解表观畸形的细微差别的研究正在引起人们的兴趣。这项研究首次阐明了Poecilia latipinna再生尾鳍的组织结构的每日变化。伤口上皮在24 hpa内形成,最终在48 hpa内分层成顶端上皮帽。在第二天,增殖细胞聚集在每个鳍状射线的前面,标志着胚泡的开始。这些细胞在远处以4 dpa表达软骨凝结的迹象。然而,在5 dpa观察到骨化和放线菌增生到鳞翅目增生。随后,再生物以可变速率生长,直到达到25 dpa的原始大小。该结果将为进一步的探索性研究提供有价值的标准参考,这些探索性研究要求在规定的时间点操纵调节信号。