Acquired immune deficiency syndrome is an epidemic infectious disease which is caused by the human immunodeficiency virus (HIV) and that has proliferated across worldwide. It has been a matter of concern for the scientific community to develop an antiretroviral therapy, which will prompt a rapid decline in viral abundance. With this motivation, this study proposes the design of a robust super twisting sliding mode controller based on output information for an uncertain HIV infection model. The control objective is to decrease the concentration of infected CD4+ T cells to a specified level by drug administration using only the output information of the uncertain HIV infection model which is total CD4+ T cell concentration. The robust output-feedback controller has been developed in combination with a robust exact differentiator, functioning as an observer. The reported analysis demonstrates that the approach proposed here is capable of ensuring robust performance under several operating conditions, measurement and modelling error, parametric uncertainties and external disturbances and the simulation results prove the proficiency of the controller proposed.

中文翻译：

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通过抗逆转录病毒治疗强有力地控制艾滋病毒感染：一种超扭曲滑动模式控制方法。

获得性免疫缺陷综合症是一种由人类免疫缺陷病毒（HIV）引起的流行性传染病，已在全球范围内扩散。开发抗逆转录病毒疗法一直是科学界关注的问题，这将促使病毒丰度迅速下降。出于这个动机，本研究提出了一种基于不确定的 HIV 感染模型的输出信息的鲁棒超扭转滑模控制器的设计。控制目标是仅使用不确定的HIV感染模型的输出信息，即总CD4+ T细胞浓度，通过给药将感染的CD4+ T细胞浓度降低至指定水平。鲁棒的输出反馈控制器是与鲁棒的精确微分器结合开发的，充当观察者。报告的分析表明，本文提出的方法能够确保在多种操作条件、测量和建模误差、参数不确定性和外部干扰下的鲁棒性能，并且仿真结果证明了所提出的控制器的熟练程度。