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The anti-bacterial iron-restriction defence mechanisms of egg white; the potential role of three lipocalin-like proteins in resistance against Salmonella.
Biometals ( IF 3.5 ) Pub Date : 2019-02-27 , DOI: 10.1007/s10534-019-00180-w
Louis Alex Julien 1, 2 , Florence Baron 2 , Sylvie Bonnassie 2, 3 , Françoise Nau 2 , Catherine Guérin 2 , Sophie Jan 2 , Simon Colin Andrews 1
Affiliation  

Salmonella enterica serovar Enteritidis (SE) is the most frequently-detected Salmonella in foodborne outbreaks in the European Union. Among such outbreaks, egg and egg products were identified as the most common vehicles of infection. Possibly, the major antibacterial property of egg white is iron restriction, which results from the presence of the iron-binding protein, ovotransferrin. To circumvent iron restriction, SE synthesise catecholate siderophores (i.e. enterobactin and salmochelin) that can chelate iron from host iron-binding proteins. Here, we highlight the role of lipocalin-like proteins found in egg white that could enhance egg-white iron restriction through sequestration of certain siderophores, including enterobactin. Indeed, it is now apparent that the egg-white lipocalin, Ex-FABP, can inhibit bacterial growth via its siderophore-binding capacity in vitro. However, it remains unclear whether Ex-FABP performs such a function in egg white or during bird infection. Regarding the two other lipocalins of egg white (Cal-γ and α-1-glycoprotein), there is currently no evidence to indicate that they sequester siderophores.

中文翻译:

蛋白的抗菌铁限制防御机制;三种脂钙蛋白样蛋白在沙门氏菌抗性中的潜在作用。

肠炎沙门氏菌肠炎沙门氏菌(SE)是欧盟食源性暴发中最常被发现的沙门氏菌。在此类暴发中,鸡蛋和蛋制品被确定为最常见的感染媒介。蛋清的主要抗菌特性可能是铁限制,这是由于铁结合蛋白卵转铁蛋白的存在所致。为了规避铁的限制,SE合成了儿茶酚酸铁载体(即Enterobactin和salmochelin),它们可以从宿主铁结合蛋白中螯合铁。在这里,我们着重介绍在蛋清中发现的类脂钙蛋白样蛋白的作用,该蛋白可以通过螯合某些铁载体(包括肠杆菌素)来增强蛋清对铁的限制。确实,现在很明显,蛋清脂质运载蛋白Ex-FABP 通过体外铁载体的结合能力可以抑制细菌的生长。但是,还不清楚Ex-FABP是否在蛋清中或在禽类感染期间发挥这种功能。关于另外两种蛋清脂蛋白(Cal-γ和α-1-糖蛋白),目前尚无证据表明它们螯合铁载体。
更新日期:2019-11-01
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