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Regulation of insulin and adipokinetic hormone/glucagon production in flies.
WIREs Mechanisms of Disease ( IF 3.1 ) Pub Date : 2019-08-04 , DOI: 10.1002/wdev.360
Muhammad Ahmad 1 , Li He 1 , Norbert Perrimon 1, 2
Affiliation  

Metabolic homeostasis is under strict regulation of humoral factors across various taxa. In particular, insulin and glucagon, referred to in Drosophila as Drosophila insulin‐like peptides (DILPs) and adipokinetic hormone (AKH), respectively, are key hormones that regulate metabolism in most metazoa. While much is known about the regulation of DILPs, the mechanisms regulating AKH/glucagon production is still poorly understood. In this review, we describe the various factors that regulate the production of DILPs and AKH and emphasize the need for future studies to decipher how energy homeostasis is governed in Drosophila.

中文翻译:

果蝇胰岛素和脂肪运动激素/胰高血糖素产生的调节。

代谢稳态受到各种分类群的体液因子的严格调节。特别是,胰岛素和胰高血糖素,在果蝇中分别称为果蝇胰岛素样肽 (DILP) 和脂肪动力激素 (AKH),是调节大多数后生动物代谢的关键激素。虽然人们对 DILP 的调节了解很多,但对调节 AKH/胰高血糖素产生的机制仍然知之甚少。在这篇综述中,我们描述了调节 DILP 和 AKH 产生的各种因素,并强调未来研究需要破译果蝇能量稳态的控制方式。
更新日期:2019-08-04
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