In September 2018, conference organizers Nava Segev (University of Illinois, Chicago) and Marino Zerial (MPI, Dresden) hosted the 5th FASEB Meeting in Small GTPases in Membrane Processes: Trafficking, Autophagy and Disease at the National Conference Center in Leesburg, Virginia. With over 100 attendees from across the globe sharing their varied expertise and interests, we came together with the common goal of gaining a better understanding of how small GTPases and their regulators act in both canonical and non-canonical pathways to conduct a diversity of essential cellular functions. A broad range of disciplines was covered in this meeting, including the study of biophysical and structural properties of these proteins, functional studies to get at the roles of these proteins in various cellular contexts (eg, ciliary function, mitophagy, cell motility, cell cycle, and development), and translational approaches to understand the greater implications of small GTPases and their regulators in multicellular systems and disease pathology. This meeting provided attendees with the opportunity to discuss pressing questions that are driving the study of small GTPases and to explore directions for the future. Of particular note, both formal talks and informal discussions very clearly highlighted the clinical importance of these proteins and pathways, the ways in which cutting edge imaging technologies are expanding our understanding of them, and the need to work better in groups to tackle the larger questions of how GTPases contribute to cellular homeostasis or dysfunction. In this meeting report, we focus upon these three themes, as they have the potential to help shape our future studies of both the biology of small GTPases and their roles in a wide array of fundamental cellular functions.

中文翻译：

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会议报告-膜工艺中的小GTPases：FASEB夏季研究会议。

2018年9月，会议组织者Nava Segev（伊利诺伊大学，芝加哥）和Marino Zerial（德累斯顿MPI）在弗吉尼亚州里斯堡的国家会议中心主办了第五届FASEB会议，会议主题是膜过程中的小GTP酶：贩运，自噬和疾病。来自全球的100多名与会者分享了他们的专业知识和兴趣，我们共同的目标是更好地了解小型GTPases及其监管者在规范和非规范途径中的行为方式，以进行多种基本细胞职能。本次会议涵盖了广泛的学科，包括这些蛋白质的生物物理和结构特性研究，功能研究，以了解这些蛋白质在各种细胞环境中的作用（例如，睫状功能，线粒体，细胞运动，细胞周期和发育）以及翻译方法，以了解小GTP酶及其调节剂在多细胞系统和疾病病理学中的更大意义。这次会议为与会人员提供了讨论推动小型GTPases研究的紧迫问题并探索未来方向的机会。特别值得注意的是，正式演讲和非正式讨论都非常清楚地强调了这些蛋白质和途径的临床重要性，尖端成像技术扩大了我们对它们的理解的方式，以及需要在小组中更好地工作以解决更大的问题GTPases如何导致细胞稳态或功能障碍。在本次会议报告中，我们重点关注这三个主题，