Background/Aim. In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. Methods. After retrospectively reviewing the data from the Helicobacter Registry in Gil Medical Center (GMC) and Asan Medical Center (AMC), along with 4 reference strains, we selected the 31 single- or multidrug-resistant strains. The susceptibility of the H. pylori strains to seven antibiotics (clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, rifabutin, and furazolidone) and minimum inhibitory concentration were tested using the broth microdilution technique. Results. Among 31 antibiotic resistance strains for H. pylori, there were no strains resistant to rifabutin or furazolidone, which had MICs of <0.008 and 0.5 μg/mL, respectively. Only one tetracycline-resistant strain was found (MIC < 2 μg/mL). Amoxicillin and levofloxacin were relatively less effective against the H. pylori strains compared to rifabutin or furazolidone (resistance rates 22.6%, 1.9%, respectively). Tetracycline showed the relatively low resistance rates (3.2%) for H. pylori strains. Conclusions. Therefore, along with tetracycline which has already been used as a component for second-line eradication regimen for Helicobacter, rifabutin and furazolidone, alone or in combination, could be used to eradicate antibiotic-resistant H. pylori strains where drug-resistant Helicobacter spp. are increasing.

中文翻译：

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利福布丁和呋喃唑酮可能成为韩国抗生素耐药性幽门螺杆菌救援方案的候选者。

背景/目标。在韩国，由于抗生素耐药性增加，特别是对克拉霉素和甲硝唑的双重耐药性，幽门螺杆菌（H. pylori ）根除率稳步下降。然而，缺乏耐药性幽门螺杆菌的微生物培养数据。这项研究评估了候选抗生素对耐药幽门螺杆菌菌株的抗菌功效。方法。在回顾性审查了吉医疗中心 (GMC) 和牙山医疗中心 (AMC)螺杆菌登记处的数据以及 4 个参考菌株后，我们选择了 31 个单一或多重耐药菌株。使用肉汤微量稀释技术测试幽门螺杆菌菌株对七种抗生素（克拉霉素、甲硝唑、左氧氟沙星、阿莫西林、四环素、利福布丁和呋喃唑酮）的敏感性和最低抑菌浓度。结果。31株幽门螺杆菌耐药菌株中，没有对利福布丁和呋喃唑酮耐药的菌株，其MIC分别<0.008和0.5μg  / mL。仅发现一种四环素耐药菌株（MIC < 2  μg /mL）。与利福布丁或呋喃唑酮相比，阿莫西林和左氧氟沙星对幽门螺杆菌菌株的疗效相对较差（耐药率分别为 22.6%、1.9%）。四环素对幽门螺杆菌菌株的耐药率相对较低（3.2%）。结论。因此，与已用作螺杆菌二线根除方案成分的四环素一起，利福布丁和呋喃唑酮单独或组合可用于根除耐药螺杆菌属的抗生素耐药性幽门螺杆菌菌株。正在增加。