Processes that are important in cancer progression, such as sustained cell growth, invasion to other organs, and resistance to cell death inducers, have a clear overlap with pathways regulated by Ca2+ signaling. It is therefore not surprising that proteins important in Ca2+ signaling, sometimes referred to as the "Ca2+ signaling toolkit," can contribute to cancer cell proliferation and invasiveness, and the ability of agents to induce cancer cell death. Ca2+ signaling is also critical in other aspects of cancer progression, including events in the tumor microenvironment and processes involved in the acquisition of resistance to anticancer therapies. This review will consider the role of Ca2+ signaling in tumor progression and highlight areas in which a better understanding of the interplay between the Ca2+-signaling toolkit and tumorigenesis is still required.

中文翻译：

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癌症中的钙信号工具包：重塑和靶向。

在癌症进展中很重要的过程，例如持续的细胞生长、对其他器官的侵袭和对细胞死亡诱导剂的抵抗，与受 Ca2+ 信号传导调节的途径有明显的重叠。因此，在 Ca2+ 信号传导中重要的蛋白质（有时称为“Ca2+ 信号传导工具包”）可以促进癌细胞增殖和侵袭性以及试剂诱导癌细胞死亡的能力也就不足为奇了。Ca2+ 信号传导在癌症进展的其他方面也很重要，包括肿瘤微环境中的事件和参与抗癌疗法获得抗性的过程。