BACKGROUND Surface modification of metallic implants is critical for improving the clinical performance of the dental and orthopedic devices. Bioactive glasses exhibit different levels of cellular function and physicochemical behavior; however, there have been few previous studies on the effect of constituents of the bioactive glasses on the in vitro osteogenic activity and corrosion resistance of apatite-based coatings. OBJECTIVE The objective of this work was to investigate the effect of SiO2, CaO, Na2O, and P2O5 on plasma-sprayed apatite coatings on Ti alloy substrates for tailoring the properties of implants making them suitable for clinical applications. METHODS The corrosion potential and corrosion current of various coatings in simulated body fluid (SBF) were examined. MG63 cell proliferation, differentiation, and mineralization of plasma-sprayed apatite-matrix coatings were evaluated. RESULTS The SiO2 and CaO-containing HA (HSC) coating had a higher corrosion potential than the other three coatings, while SiO2-containing HA (HS) coating displayed the highest corrosion current among all coatings. The effect of the oxides on cell functions followed the order SiO2 > CaO > P2O5 > Na2O in terms of cell attachment, proliferation, differentiation, and mineralization. CONCLUSIONS The flexibility in oxide doping may allow for the tunable biological properties and corrosion-resistant ability of the apatite coatings.

中文翻译：

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生物活性玻璃对磷灰石基体涂层的耐腐蚀性和体外生物学性能的影响。

背景技术金属植入物的表面改性对于改善牙科和矫形设备的临床性能至关重要。生物活性玻璃表现出不同水平的细胞功能和理化行为。然而，关于生物活性玻璃的成分对磷灰石基涂层的体外成骨活性和耐腐蚀性的影响，以前的研究很少。目的这项工作的目的是研究SiO2，CaO，Na2O和P2O5对Ti合金基底上等离子喷涂磷灰石涂层的影响，以调整植入物的性能，使其适合临床应用。方法检查了各种涂层在模拟体液（SBF）中的腐蚀电位和腐蚀电流。MG63细胞的增殖，分化，评估了等离子喷涂磷灰石基体涂层的矿化程度。结果含SiO2和CaO的HA（HSC）涂层具有比其他三种涂层更高的腐蚀潜能，而含SiO2和HAO的HA（HS）涂层在所有涂层中表现出最高的腐蚀电流。在细胞附着，增殖，分化和矿化方面，氧化物对细胞功能的影响遵循SiO2> CaO> P2O5> Na2O的顺序。结论氧化物掺杂的灵活性可以使磷灰石涂层具有可调节的生物学特性和耐腐蚀能力。含SiO2的HA（HS）涂层在所有涂层中表现出最高的腐蚀电流。在细胞附着，增殖，分化和矿化方面，氧化物对细胞功能的影响遵循SiO2> CaO> P2O5> Na2O的顺序。结论氧化物掺杂的灵活性可以使磷灰石涂层具有可调节的生物学特性和耐腐蚀能力。含SiO2的HA（HS）涂层在所有涂层中表现出最高的腐蚀电流。在细胞附着，增殖，分化和矿化方面，氧化物对细胞功能的影响遵循SiO2> CaO> P2O5> Na2O的顺序。结论氧化物掺杂的灵活性可以使磷灰石涂层具有可调节的生物学特性和耐腐蚀能力。