Introduction. Cognitive impairment frequently occurs in adult patients with epilepsy (PWE), but its pathophysiological basis is not well known. This study assessed cognition and its correlations with quantitative EEG coherence (QEEG) of patients with epilepsy. Method. Eighty PWE seen consecutively in the clinic and 40 normal subjects (NC) were assessed by neurological evaluation, Mini Mental State Examination, immediate and delayed recall of 10 simple figures, phonemic verbal fluency (FAS), category fluency test (VF animals), clock drawing, and QEEG. The mean global inter- and intrahemispheric coherences for the delta, theta, alpha, and beta bands were calculated. Cognitive functions and QEEG coherence of the PWE and the NC were compared, and logistic regression analysis determined the factors associated with impaired cognitive functions in PWE. The significance level was set at P < .05. Results. Regression analysis showed that FAS impairment (14.5 ± 8.6 vs 24.3 ± 15.7, respectively) and delayed recall of figures in PWE (7.3 ± 2.07 vs 8.6 ± 1.48) differed significantly between the PWE and the NC (Nagelkerke R2 = 0.266). Absolute power was greater in all the frequency bands in PWE. Interhemispheric and intrahemispheric beta coherences in the theta frequency was higher in the PWE than in the NC. Logistic regression analysis showed a significant association between interhemispheric delta coherence and VF animal impairment (cutoff point of 12), and between an interhemipheric beta coherence with level of education and delayed recall of figures impairment (cutoff point of 7) (Nagelkerke R2 = 0.297). Other variables were not associated. Conclusions. There was cognitive impairment of PWE and it was significantly associated with QEEG, which suggests that QEEG measures may contribute to the understanding of physiopathological events and as a marker for cognitive alterations in epilepsy.

中文翻译：

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成人癫痫患者认知方面与定量脑电图的相关性

介绍。成人癫痫 (PWE) 患者常发生认知障碍，但其病理生理学基础尚不清楚。本研究评估了癫痫患者的认知及其与定量 EEG 相干性 (QEEG) 的相关性。方法。通过神经学评估、简易精神状态检查、10个简单数字的即时和延迟回忆、音素语言流畅度（FAS）、类别流畅度测试（VF动物）、时钟对80名在诊所连续看到的PWE和40名正常人（NC）进行评估绘图和 QEEG。计算了 delta、theta、alpha 和 beta 波段的平均全球半球间和半球内相干性。比较了 PWE 和 NC 的认知功能和 QEEG 一致性，逻辑回归分析确定了 PWE 认知功能受损的相关因素。显着性水平设为 P < .05。结果。回归分析表明 PWE 和 NC 之间的 FAS 损伤（分别为 14.5 ± 8.6 和 24.3 ± 15.7）和延迟回忆数字（7.3 ± 2.07 对 8.6 ± 1.48）在 PWE 和 NC 之间存在显着差异（Nagelkerke R2 = 0.266）。PWE 中所有频段的绝对功率都更大。PWE 中的半球间和半球内 β 相干性在 θ 频率中高于 NC。Logistic 回归分析显示半球间 delta 连贯性与 VF 动物损伤（截止点为 12）之间，以及半球间β 连贯性与教育水平和数字障碍延迟回忆之间（截止点为 7）之间存在显着关联（Nagelkerke R2 = 0.297） . 其他变量不相关。结论。