DDR1 and DDR2 are expressed in skin but their expression differs according to the skin compartment, epidermis, dermis, hypodermis and to the embryonic origin of the cells. In skin, it seems that during physiological processes such as wound healing or pathological processes such as tumorigenesis or systemic sclerosis development only one of the DDR is dysregulated. Furthermore, the altered DDR in pathological process is not necessarily the DDR implicated in basal homeostasis. Indeed, in epidermis, while DDR1 is the main DDR involved in melanocyte homeostasis, DDR2 seems to be the main DDR implicated in melanoma. On the contrary, in dermis, while DDR2 is necessary for normal wound healing, dysregulation of DDR1 is associated with abnormal wound healing leading to keloid. In conclusion, targeting DDR could be a therapeutic solution, however side effects have to be managed carefully.

中文翻译：

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皮肤中的DDR1和DDR2。

DDR1和DDR2在皮肤中表达，但它们的表达根据皮肤区室，表皮，真皮，皮下组织和细胞的胚胎起源而不同。在皮肤中，似乎在诸如伤口愈合的生理过程或诸如肿瘤发生或系统性硬化发展的病理过程中，只有一种DDR失调。此外，在病理过程中改变的DDR不一定与基础动态平衡有关。确实，在表皮中，虽然DDR1是涉及黑色素细胞稳态的主要DDR，但DDR2似乎是与黑色素瘤有关的主要DDR。相反，在真皮中，尽管DDR2对于正常的伤口愈合是必需的，但DDR1的失调与异常的伤口愈合相关，从而导致瘢痕loid。总之，针对DDR可能是一种治疗方案，