In this extra view, we comment on our recent work concerning the mRNA localization of the gene slow as molasses (slam). slam is a gene essential for the polarized invagination of the plasma membrane and separation of basal and lateral cortical domains during cellularization as well as for germ cell migration in later embryogenesis. We have demonstrated an intimate relationship between slam RNA and its encoded protein. Slam RNA co-localizes and forms a complex with its encoded protein. Slam mRNA localization not only is required for reaching full levels of functional Slam protein but also depends on Slam protein. The translation of slam mRNA is subject to tight spatio-temporal regulation leading to a rapid accumulation of Slam protein and zygotic slam RNA at the furrow canal. In this extra view, we first discuss the mechanism controlling localization and translation of slam RNA. In addition, we document in detail the maternal and zygotic expression of slam RNA and protein and provide data for a function in membrane stabilization. Furthermore, we mapped the region of Slam protein mediating cortical localization in cultured cells.

在这个额外的观点中，我们评论了我们最近关于糖蜜（slam）慢基因的mRNA定位的工作。slam是细胞化过程中质膜极化内陷，基础和外侧皮质结构域分离以及以后胚胎发生中生殖细胞迁移所必需的基因。我们已经证明了满贯RNA及其编码的蛋白质之间的密切关系。Slam RNA共定位并与其编码的蛋白质形成复合物。Slam mRNA定位不仅需要达到功能性Slam蛋白的最高水平，还取决于Slam蛋白。slam的翻译mRNA受严格的时空调节，导致Slam蛋白和合子Slam RNA在沟渠中快速积累。在这个额外的观点中，我们首先讨论控制Slam RNA定位和翻译的机制。此外，我们详细记录了Slam RNA和蛋白质的母体和合子表达，并提供了膜稳定功能的数据。此外，我们绘制了在培养细胞中介导皮质定位的Slam蛋白区域。