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Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation.
Cold Spring Harbor Perspectives in Biology ( IF 7.2 ) Pub Date : 2020-01-02 , DOI: 10.1101/cshperspect.a035170
Sarah E Webb 1 , Jeffrey J Kelu 1 , Andrew L Miller 1
Affiliation  

Since the identification of nicotinic acid adenine dinucleotide phosphate (NAADP) and its putative target, the two-pore channel (TPC), the NAADP/TPC/Ca2+ signaling pathway has been reported to play a role in a diverse range of functions in a variety of different cell types. TPCs have also been associated with a number of diseases, which arise when their activity is perturbed. In addition, TPCs have been shown to play key roles in various embryological processes and during the differentiation of a variety of cell types. Here, we review the role of NAADP/TPC/Ca2+ signaling during early embryonic development and cellular differentiation. We pay particular attention to the role of TPC2 in the development and maturation of early neuromuscular activity in zebrafish, and during the differentiation of isolated osteoclasts, endothelial cells, and keratinocytes. Our aim is to emphasize the conserved features of TPC-mediated Ca2+ signaling in a number of selected examples.

中文翻译:

双孔通道在胚胎发育和细胞分化中的作用。

自从鉴定出烟酸腺嘌呤二核苷酸磷酸 (NAADP) 及其假定靶标双孔通道 (TPC) 以来,NAADP/TPC/Ca2+ 信号通路已被报道在多种功能中发挥作用。不同的细胞类型。TPC 还与许多疾病有关,这些疾病是在 TPC 的活性受到干扰时发生的。此外,TPC 已被证明在各种胚胎学过程和各种细胞类型的分化过程中发挥着关键作用。在这里,我们回顾了 NAADP/TPC/Ca2+ 信号在早期胚胎发育和细胞分化过程中的作用。我们特别关注 TPC2 在斑马鱼早期神经肌肉活动的发育和成熟中以及在分离的破骨细胞、内皮细胞和角质形成细胞的分化过程中的作用。我们的目的是在一些选定的例子中强调 TPC 介导的 Ca2+ 信号传导的保守特征。
更新日期:2019-11-01
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