Calcium (Ca²⁺) ion microdomains are subcellular regions of high Ca²⁺ concentration that develop rapidly near open Ca²⁺ channels in the plasma membrane or internal stores and generate local regions of high Ca²⁺ concentration. These microdomains are remarkably versatile in that they activate a range of responses that differ enormously in both their temporal and spatial profile. In this review, we describe how Ca²⁺ microdomains generated by store-operated calcium channels, a widespread and conserved Ca²⁺ entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca²⁺ microdomain can be influenced by Ca²⁺ ATPase pumps.

中文翻译：

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从存储操作的 CRAC 通道通过 Ca2+ 微域发出信号。

钙 (Ca ²⁺ ) 离子微区是高 Ca ²⁺浓度的亚细胞区域，它们在质膜或内部储存中的开放 Ca ^{2+通道附近迅速发展，并产生高 Ca 2+}浓度的局部区域。这些微域非常通用，因为它们激活了一系列在时间和空间分布上都大不相同的反应。在这篇综述中，我们描述了由储存操作的钙通道（一种广泛且保守的 Ca ^{2+进入途径）生成的 Ca 2+}微区如何刺激不同的信号通路，以及 Ca ²⁺微区的空间范围如何受 Ca 的影响。²⁺ATP酶泵。