Abstract

Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1–3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT₁ and MT₂ receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC₅₀ value of 76.24 μM on MT₂ receptor.

Graphic Abstract

中文翻译：

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天麻酚类的褪黑素受体激动活性。

摘要

天麻是一种药食两用的名贵中药材。在本研究中，从G. elata的 EtOAc 提取物中分离出三种新的聚苄基，胃聚苯甲基酚 GI ( 1-3 )。它们的结构通过涉及 HRESIMS、UV、IR、1D 和 2D NMR 的广泛光谱分析进行了鉴定。化合物1对MT ₁和MT ₂受体具有激动作用，浓度为0.5 mM时，激动率分别为55.91±4.84%和165.13±5.65%，对MT _{2受体的EC 50}值为76.24  μM。

图文摘要