Abstract

Four new protopanaxatriol-type triterpenes (1–2) and glucosides (3–4), were isolated from the rot roots of Panax notoginseng (Burk.) Chen, along with four known ones (5–8). Their structures were elucidated on the basis of extensive spectroscopic analysis (HRESIMS, NMR, UV, IR, and OR) and acidic hydrolysis. The possible transformation pathway of these compounds were also speculated from ginsenoside Rg₁. Compound 1, with a unique α,β-unsaturated ketene in its side chain, showed significant inhibitory effects against NO production on Murine macrophage cells (IC₅₀ = 4.12 ± 0.20 μM) and comparable cytotoxicities against five human cancer cell lines (myeloid leukemia HL-60, lung cancer A-549 cells, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480) to positive control, cisplatin (DDP).

Graphical Abstract

中文翻译：

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三七腐烂根的抗炎和细胞毒性三萜。

摘要

四个新的原人参萜三醇型三萜类化合物（1 - 2）和葡糖苷（3 - 4），是从的腐根中分离三七（伯克）陈，具有四个公知的（沿5 - 8）。在广泛的光谱分析（HRESIMS，NMR，UV，IR和OR）和酸性水解的基础上阐明了它们的结构。这些化合物的可能转化途径也由人参皂苷Rg ₁推测。化合物1在其侧链中具有独特的α，β-不饱和烯酮，显示出对鼠巨噬细胞的NO产生显着的抑制作用（IC ₅₀ = 4.12±0.20μM）和对五种人类癌细胞系（髓样白血病HL-60，肺癌A-549细胞，肝细胞癌SMMC7721，乳腺癌MCF-7和结肠癌SW480）的细胞毒性与阳性对照，顺铂（ DDP）。

图形概要