Trans-resveratrol (TR) is the biological active isomer of resveratrol and the one responsible for therapeutic effects; both molecules are non-flavonoid phenolics of the stilbenes class found mainly in berries and red grapes. TR biological properties lie in modulation of various enzymatic classes. It is a promising candidate to novel drugs due its applications in pharmaceutical and cosmetic industries, such as anticarcinogenic, antidiabetic, antiacne, antioxidant, anti-inflammatory, neuroprotective, and photoprotector agent. It has effects on bone metabolism, gastrointestinal tract, eyes, kidneys, and in obesity treatment as well. Nevertheless, its low solubility in water and other polar solvents may be a hindrance to its therapeutic effects. Various strategies been developed to overcome these issues, such as the drug delivery systems. The present study performed a research about methods to identify TR and RESV in several samples (raw materials, wines, food supplements, drug delivery systems, and blood plasma). Most of the studies tend to analyze TR and RESV by high performance liquid chromatography (HPLC) coupled with different detectors, even so, there are reports of the use of capillary electrophoresis, electron spin resonance, gas chromatography, near-infrared luminescence, UV-Vis spectrophotometer, and vibrational spectrophotometry, for this purpose. Thus, the review evaluates the biological activity of TR and demonstrates the currently used analytical methods for its quantification in different matrices.

反式-白藜芦醇（TR）是白藜芦醇的生物活性异构体，是一种负责治疗作用的异构体；这两个分子均为丁苯类的非类黄酮酚醛，主要存在于浆果和红葡萄中。TR的生物学特性在于各种酶类别的调节。由于其在药物和化妆品工业中的应用，例如抗癌，抗糖尿病，抗痤疮，抗氧化剂，抗炎，神经保护和光保护剂，它是新药的有希望的候选者。它对骨骼代谢，胃肠道，眼睛，肾脏以及肥胖症治疗都有影响。然而，其在水和其他极性溶剂中的低溶解度可能会阻碍其治疗效果。已经开发了克服这些问题的各种策略，例如药物输送系统。本研究进行了有关鉴定几种样品（原料，葡萄酒，食品补充剂，药物递送系统和血浆）中TR和RESV的方法的研究。大多数研究倾向于通过结合不同检测器的高效液相色谱（HPLC）分析TR和RESV，即使如此，也有报道使用毛细管电泳，电子自旋共振，气相色谱，近红外发光，UV-为此，使用了可见分光光度计和振动分光光度法。因此，本综述评估了TR的生物学活性，并证明了目前在不同基质中定量使用TR的分析方法。大多数研究倾向于通过结合不同检测器的高效液相色谱（HPLC）分析TR和RESV，即使如此，也有报道使用毛细管电泳，电子自旋共振，气相色谱，近红外发光，UV-为此，使用了可见分光光度计和振动分光光度法。因此，本综述评估了TR的生物学活性，并证明了目前在不同基质中定量使用TR的分析方法。大多数研究倾向于通过结合不同检测器的高效液相色谱（HPLC）分析TR和RESV，即使如此，也有报道使用毛细管电泳，电子自旋共振，气相色谱，近红外发光，UV-为此，使用了可见分光光度计和振动分光光度法。因此，本综述评估了TR的生物学活性，并证明了目前在不同基质中定量使用TR的分析方法。