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Effects of a Fermented Beverage of Changbai Mountain Fruit and Vegetables on the Composition of Gut Microbiota in Mice
Plant Foods for Human Nutrition ( IF 4 ) Pub Date : 2019-07-27 , DOI: 10.1007/s11130-019-00761-7
Yan Wang 1 , Miao Yu 1 , Yongwei Shi 2 , Tong Lu 1 , Wenhui Xu 1 , Yaqiong Sun 1 , Lutong Yang 1 , Zhenwei Gan 3 , Lin Xie 1
Affiliation  

Evidence suggests that fermented foods and beverages made from fruits and vegetables benefit human health, including in the prevention of cardiovascular disease, cancer, diabetes and gastrointestinal disorders. However, there are few studies on the effects of fermented fruits and vegetables on intestinal microbiota. In this study, we investigated the changes in the composition of the intestinal microbial community after short-term treatment with a fermented beverage of Changbai Mountain fruit and vegetables (FB). Forty male ICR mice, weighing 17–19 g, were fed diets with different concentrations of the FB or distilled water for 15 days. 16S rDNA gene sequences were used to analyze the gut microbiota with the Illumina sequencing platform and a paired-end method. FB had no effect on weight gain, the adiposity index, or food intake in the treated mice compared with the control group. The cecal index was significantly higher in the FB-administered groups than in the control group. Firmicutes and Bacteroidetes were the dominant phyla in the mice ceca. The Firmicutes/Bacteroidetes ratio was reduced in the FB-administered mice, and proportions of the family Prevotellaceae, Bacteroidales_S24–7_group, family Bacteroidaceae, and genus Bacteroides increased, and these increases were correlated positively with intake of fermented beverage. The FB also altered the diversity of the cecal microbiota in the mice. Graphical Abstract Graphical Abstract

中文翻译:

长白山果蔬发酵饮料对小鼠肠道菌群组成的影响

有证据表明,由水果和蔬菜制成的发酵食品和饮料有益于人类健康,包括预防心血管疾病、癌症、糖尿病和胃肠道疾病。然而,关于发酵水果和蔬菜对肠道微生物群的影响的研究很少。在这项研究中,我们研究了用长白山果蔬发酵饮料(FB)短期处理后肠道微生物群落组成的变化。40 只体重 17-19 克的雄性 ICR 小鼠被喂食含有不同浓度 FB 或蒸馏水的饮食 15 天。16S rDNA 基因序列用于通过 Illumina 测序平台和双端法分析肠道微生物群。FB 对体重增加、肥胖指数、或与对照组相比,治疗组小鼠的食物摄入量。FB给药组的盲肠指数显着高于对照组。厚壁菌门和拟杆菌门是小鼠盲肠中的优势门。FB给药小鼠的厚壁菌门/拟杆菌门比例降低,普氏菌科、拟杆菌属_S24-7_组、拟杆菌科和拟杆菌属的比例增加,这些增加与发酵饮料的摄入量呈正相关。FB 还改变了小鼠盲肠微生物群的多样性。图形摘要图形摘要 FB给药小鼠的厚壁菌门/拟杆菌门比例降低,普氏菌科、拟杆菌属_S24-7_组、拟杆菌科和拟杆菌属的比例增加,这些增加与发酵饮料的摄入量呈正相关。FB 还改变了小鼠盲肠微生物群的多样性。图形摘要图形摘要 FB给药小鼠的厚壁菌门/拟杆菌门比例降低,普氏菌科、拟杆菌属_S24-7_组、拟杆菌科和拟杆菌属的比例增加,这些增加与发酵饮料的摄入量呈正相关。FB 还改变了小鼠盲肠微生物群的多样性。图形摘要图形摘要
更新日期:2019-07-27
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