We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (N = 72), Torreón (N = 396) and rural communities (N = 216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Coahuila are European (49.72 ± 4.18% by ML; 37.49% of European haplotypes) and Native American (45.01 ± 2.69% by ML; 42.98% of Native American haplotypes), while African genetic component is less apparent (5.27 ± 1.88% by ML; 9.92% of African haplotypes).

我们研究了HLA I类（HLA-A，-B）和II类（HLA-DRB1，-DQB1）基于PCR-SSP的等位基因来自居住在萨尔蒂约（N = 72），托雷隆（N = 396）和农村社区（N = 216）的Coahuila州的墨西哥人，以获得有关等位基因和单倍型频率的信息。我们发现在科阿韦拉州发现的十种最常见的单体型包括八种美洲原住民和两种欧洲单体型。外加剂估计表明，科阿韦拉州的主要遗传成分是欧洲的（按ML分类为49.72±4.18％；欧洲的单倍型为37.49％）和美洲原住民的（ML按45.01±2.69％；美国原住民的42.98％），而非洲人为非洲遗传成分不太明显（按ML方法，为5.27±1.88％；非洲单倍型的9.92％）。