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Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco.
Human Immunology ( IF 2.7 ) Pub Date : 2019-07-23 , DOI: 10.1016/j.humimm.2019.07.286
Raúl Solís-Martínez 1 , Rodrigo Barquera 2 , Komathi Sree Ponnandai-Shanmugavel 3 , María Del Rosario Vega-Martínez 4 , Tannya Verónica Vázquez-Castillo 1 , Esteban Arrieta-Bolaños 5 , Stephen Clayton 3 , Diana Iraíz Hernández-Zaragoza 6 , Alicia Bravo-Acevedo 7 , Alexander Immel 8 , Norma Salgado-Galicia 4 , Joaquín Zúñiga 9 , Edmond J Yunis 10 , Carolina Bekker-Méndez 11 , Julio Granados 12
Affiliation  

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79 ± 1.59% by ML; 56.25% of Native American haplotypes) and European (27.21 ± 3.97% by ML; 29.91% of European haplotypes), and a less prominent African genetic component (5.01 ± 4.42% by ML; 8.93% of African haplotypes).



中文翻译:

来自墨西哥塔巴斯科州的两个种群Hilla系统的遗传多样性:比亚埃尔莫萨和塔巴斯科乡村。

我们通过基于PCR-SSP的打字方法研究了HLA I类(HLA-A-B)和II类(HLA-DRB1-DQB1)等位基因,来自居住在Villahermosa(N = 82)的塔巴斯科州的224名墨西哥人和农村社区(N = 142),以获取有关等位基因和单倍型频率的信息。我们发现塔巴斯科州最常见的单倍型包括13个美洲原住民和两个欧洲单倍型。外加剂的估计显示,塔巴斯科州的主要遗传成分是美洲原住民(按ML分类为67.79±1.59%;美国原住民单倍型为56.25%)和欧洲(按ML分类为27.21±3.97%;欧洲单倍型为29.91%),以及不太显着的非洲遗传成分(按ML值5.01±4.42%;非洲单倍型的8.93%)。

更新日期:2019-07-23
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