The transcription factor RUNX3 is a prominent regulator of multiple hematopoietic cell lineages. Gene loss of function studies demonstrated the unique and essential roles of this master regulator in differentiated lymphoid and myeloid cells. As a complementary approach, RUNX3 was upregulated in various leukocyte subsets to probe the instructive role of this 'multilineage'-specific transcription factor. In this report, we overview the immunomodulatory functions of RUNX3 within the hematopoietic compartment to gain insight into the consequences of Runx3 deletion or overexpression in committed immune cells. Genetic studies revealed the essential role of RUNX3 in Langerhans cell development. Moreover, this transcription factor is necessary for the differentiation and maintenance of the cytotoxic CD8+ T cells. In addition, T helper, natural killer, and B cells are also influenced by RUNX3. Importantly, the ectopic expression of Runx3 enhances the immunogenicity of cytotoxic T cells and pluripotent stem-cell-derived dendritic cells, suggesting that this protein can be applied in cell-based immunotherapies.

中文翻译：

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RUNX3介导的免疫细胞发育和成熟。

转录因子RUNX3是多种造血细胞谱系的重要调节剂。基因功能丧失研究证明了该主调节剂在分化的淋巴样和髓样细胞中的独特和必要的作用。作为一种补充方法，RUNX3在各种白细胞亚群中上调，以探讨这种“多谱系”特异性转录因子的指导作用。在本报告中，我们概述了造血室内RUNX3的免疫调节功能，以了解Runx3在定型免疫细胞中缺失或过表达的后果。遗传研究揭示了RUNX3在Langerhans细胞发育中的重要作用。此外，该转录因子对于细胞毒性CD8 + T细胞的分化和维持是必需的。另外，T助手 自然杀手，B细胞也受到RUNX3的影响。重要的是，Runx3的异位表达增强了细胞毒性T细胞和多能干细胞衍生的树突状细胞的免疫原性，表明该蛋白可用于基于细胞的免疫疗法。