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ADF/cofilin regulation from a structural viewpoint.
Journal of Muscle Research and Cell Motility ( IF 2.7 ) Pub Date : 2019-07-25 , DOI: 10.1007/s10974-019-09546-6
Akihiro Narita 1
Affiliation  

ADF/cofilins disassemble the actin filament and contribute to a wide range of actin dynamics. These proteins are regulated by several factors, including phosphorylation, pH and mechanical forces. Although the cofilin-decorated actin filament structure was published recently, the mechanisms of these regulating factors remain unclear. Models that describe regulation based on the latest structural data and research will be discussed. Aspects about the interaction between actin and cofilin that require further investigation are also discussed.

中文翻译:

从结构角度看ADF / cofilin调节。

ADF / cofilins分解肌动蛋白丝,并有助于广泛的肌动蛋白动力学。这些蛋白质受多种因素调节,包括磷酸化,pH和机械力。虽然最近发表了用cofilin装饰的肌动蛋白丝结构,但这些调节因子的机制仍不清楚。将讨论基于最新结构数据和研究描述监管的模型。还讨论了需要进一步研究的关于肌动蛋白和纤溶蛋白之间相互作用的方面。
更新日期:2019-07-25
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