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Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos.
Human Immunology ( IF 2.7 ) Pub Date : 2019-07-22 , DOI: 10.1016/j.humimm.2019.07.289
Andrea Ortega-Yáñez 1 , Rodrigo Barquera 2 , Laura Curiel-Giles 3 , Julio César Martínez-Álvarez 4 , Rosa María Macías-Medrano 5 , Esteban Arrieta-Bolaños 6 , Stephen Clayton 7 , Alicia Bravo-Acevedo 8 , Diana Iraíz Hernández-Zaragoza 9 , Alexander Immel 10 , María Del Rosario Vega-Martínez 11 , Gamaliel Benítez-Arvizu 12 , María Araceli Arrazola-García 4 , Agustín Jericó Arriaga-Perea 5 , Eva Dolores Juárez-Cortés 5 , Vicencio Juárez-Barreto 13 , Norma Salgado-Galicia 11 , Bárbara Novelo-Garza 14 , Joaquín Zúñiga 15 , Edmond J Yunis 16 , Carolina Bekker-Méndez 17 , Julio Granados 18
Affiliation  

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (N = 82) and rural communities (N = 30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in Morelos are Native American (60.43 ± 2.22% by ML; 53.57% of Native American haplotypes) and European (39.58 ± 3.70% by ML; 27.68% of European haplotypes), and a virtually absent African genetic component (0.00 ± 4.93% by ML; but 11.16% of African haplotypes).



中文翻译:

来自墨西哥莫雷洛斯州的两个种群中的HLA系统的遗传多样性:库埃纳瓦卡和莫雷洛斯州农村。

我们通过基于PCR-SSP的方法研究了生活在Cuernavaca市的莫雷洛斯州的112名墨西哥人中的HLA I类(HLA-A-B)和II类(HLA-DRB1-DQB1)等位基因(N = 82)和农村社区(N = 30),以获取有关等位基因和单倍型频率的信息。莫雷洛斯州最常见的单倍型包括七种美洲原住民,一种欧洲,一种非洲和一种亚洲单倍。混合物估计显示,莫雷洛斯州的主要遗传成分是美洲原住民(按ML分类为60.43±2.22%;美国原住民单倍型为53.57%)和欧洲(按ML分类为39.58±3.70%;欧洲单倍型为27.68%),以及几乎没有非洲人遗传成分(按ML计为0.00±4.93%;但为非洲单倍型的11.16%)。

更新日期:2019-07-22
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