F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.,Annals of Clinical and Translational Neurology

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F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.
Annals of Clinical and Translational Neurology ( IF 5.3 ) Pub Date : 2015-06-18 , DOI: 10.1002/acn3.223
Giuseppe Tosto ₁ , Hongjun Fu ₂ , Badri N Vardarajan ₁ , Joseph H Lee ₁ , Rong Cheng ₁ , Dolly Reyes-Dumeyer ₁ , Rafael Lantigua ₃ , Martin Medrano ₄ , Ivonne Z Jimenez-Velazquez ₅ , Mitchell S V Elkind ₆ , Clinton B Wright ₇ , Ralph L Sacco ₈ , Margaret Pericak-Vance ₉ , Lindsay Farrer ₁₀ , Ekaterina Rogaeva ₁₁ , Peter St George-Hyslop ₁₂ , Christiane Reitz ₁₃ , Richard Mayeux ₁₄

Affiliation

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, School of Public Health, Columbia University New York, New York ; The Gertrude H. Sergievsky Center, School of Public Health, Columbia University New York, New York.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, School of Public Health, Columbia University New York, New York.
Department of Medicine College of Physicians and Surgeons, School of Public Health, Columbia University New York, New York.
School of Medicine, Pontificia Universidad Catolica Madre y Maestra Santiago, Dominican Republic.
Department of Medicine, Geriatrics Program, School of Medicine, University of Puerto Rico San Juan, Puerto Rico.
The Gertrude H. Sergievsky Center, School of Public Health, Columbia University New York, New York ; Department of Neurology, Columbia University New York, New York.
Evelyn F. McKnight Brain Institute and Departments of Neurology, Public Health Sciences, John T. McDonald Department of Human Genetics, University of Miami Miami, Florida, 33136.
Evelyn F. McKnight Brain Institute and Departments of Neurology, Public Health Sciences, John T. McDonald Department of Human Genetics, University of Miami Miami, Florida, 33136 ; Neuroscience Program, Leonard M. Miller School of Medicine, University of Miami Miami, Florida, 33136.
Neuroscience Program, Leonard M. Miller School of Medicine, University of Miami Miami, Florida, 33136 ; The John P. Hussman Institute for Human Genomics, University of Miami Miami, Florida, 33136.
Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Biostatistics and Epidemiology, Boston University Schools of Medicine and Public Health Boston, Massachusetts.
Tanz Centre for Research in Neurodegenerative Diseases, and Department of Medicine, University of Toronto Krembil Discovery Tower, 60 Leonard Avenue, Toronto, Ontario, Canada, M5T 2S8.
Tanz Centre for Research in Neurodegenerative Diseases, and Department of Medicine, University of Toronto Krembil Discovery Tower, 60 Leonard Avenue, Toronto, Ontario, Canada, M5T 2S8 ; Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge Cambridge, CB2 0XY, United Kingdom.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, School of Public Health, Columbia University New York, New York ; The Gertrude H. Sergievsky Center, School of Public Health, Columbia University New York, New York ; Department of Neurology, Columbia University New York, New York.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, School of Public Health, Columbia University New York, New York ; The Gertrude H. Sergievsky Center, School of Public Health, Columbia University New York, New York ; Department of Neurology, Columbia University New York, New York ; Department of Psychiatry, School of Public Health, Columbia University New York, New York ; Department of Epidemiology, School of Public Health, Columbia University New York, New York.

In the context of late‐onset Alzheimer's disease (LOAD) over 20 genes have been identified but, aside APOE, all show small effect sizes, leaving a large part of the genetic component unexplained. Admixed populations, such as Caribbean Hispanics, can provide a valuable contribution because of their unique genetic profile and higher incidence of the disease. We aimed to identify novel loci associated with LOAD.

中文翻译：

F-box/LRR 重复蛋白 7 在遗传上与阿尔茨海默病有关。

在迟发性阿尔茨海默病 (LOAD) 的背景下，已鉴定出 20 多个基因，但除了APOE外，所有基因都显示出较小的影响大小，导致大部分遗传成分无法解释。混合人群，如加勒比西班牙裔，由于其独特的遗传特征和较高的疾病发病率，可以提供有价值的贡献。我们旨在确定与 LOAD 相关的新基因座。

更新日期：2015-06-18

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