A large body of evidence that has accumulated over the past decade strongly supports the role of both blood-brain barrier (BBB) dysfunction and perivascular inflammation in the pathophysiology of epilepsy. Recent preclinical studies indicate that prolonged seizure- or brain injury-induced BBB dysfunction and subsequent perivascular inflammation may play an important role in post-traumatic epileptogenesis. In turn, perivascular inflammation can further sustain BBB dysfunction. In genetic epilepsies, such as tuberous sclerosis complex and other related epileptogenic developmental pathologies, there is an association between the underlying gene mutation, BBB dysfunction, and perivascular inflammation, but evidence for a causal link to epilepsy is lacking. Future neuroimaging studies might shed light on the role of BBB function in different epilepsies and address the potential for disease modification by targeting both the BBB and perivascular inflammation in acquired and genetic epilepsies.

中文翻译：

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屋顶漏水，狂风暴雨肆虐：在对抗癫痫病中修复血脑屏障。

在过去十年中积累的大量证据强烈支持血脑屏障（BBB）功能障碍和血管周围炎症在癫痫的病理生理学中的作用。最近的临床前研究表明，癫痫发作或脑损伤引起的BBB功能障碍延长以及随后的血管周围炎症可能在创伤后癫痫发生中起重要作用。反过来，血管周围炎症可进一步维持BBB功能障碍。在遗传性癫痫病中，例如结节性硬化症和其他相关的癫痫发生发展病理，潜在的基因突变，BBB功能障碍和血管周炎症之间存在关联，但缺乏与癫痫病因果关系的证据。