Context: Metabolic imbalance in renal cell carcinoma (RCC) can lead to abnormal adiponectin levels. Objective: To evaluate circulating adiponectin as a detection or predictive marker for RCC. Methods: A comprehensive literature search and meta-analysis was performed on studies reporting circulating adiponectin levels and RCC. The meta-analysis was performed using RevMan. Results: Seven studies compared the circulating adiponection levels between RCC cases and controls. Adiponectin level was significantly lower in RCC cases compared to controls at pre-diagnosis and pre-operative time-points. RCC stage, grade and subtype did not affect adiponectin levels. Conclusion: Low circulating adiponectin could be a predictive or risk factor for RCC.

中文翻译：

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循环脂联素作为肾细胞癌中的生物标志物：系统评价和荟萃分析。

背景：肾细胞癌（RCC）的代谢失衡可导致脂联素水平异常。目的：评估循环脂联素作为RCC的检测或预测指标。方法：对报告脂联素水平和RCC的研究进行了全面的文献检索和荟萃分析。荟萃分析使用RevMan进行。结果：七项研究比较了RCC病例和对照组之间的循环脂肪吸收水平。在诊断前和手术前，与对照组相比，RCC患者的脂联素水平显着降低。RCC分期，等级和亚型不影响脂联素水平。结论：低脂联素可能是RCC的预测或危险因素。