Context: Differential expression profiles of microRNAs have been reported in human obesity suggesting a miRNAs role in the development of obesity and associated disorders. Objective: To review circulating microRNAs (c-miRNAs) dysregulated in human obesity and to predict their possible target genes. Methods: We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and human obesity and recorded c-miRNAs with differential expression profiles. Potential target genes and metabolic pathways for dysregulated miRNAs with at least two independent reports were searched using bioinformatic tools. Results: Twenty-two c-miRNAs are overexpressed, nine underexpressed and two c-miRNAs dysregulated in both directions in people with obesity compared to lean controls. Bioinformatic analyses suggest these c-miRNAs target on genes associated with fatty acid metabolism and PI3k/Akt pathway. Conclusion: Literature records 33 c-miRNAs confirmedly dysregulated in human obesity. Their predicted target genes are involved in pathways that could explain the development of obesity and its comorbidities. Further research will clarify the role of these miRNAs on metabolic diseases and their usefulness for the prognosis, prevention and treatment of obesity.

中文翻译：

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人类肥胖中的循环microRNA：系统综述。

背景：在人类肥胖症中已报道了microRNA的差异表达谱，这表明miRNA在肥胖症和相关疾病的发展中具有重要作用。目的：审查人类肥胖中失调的循环微RNA（c-miRNA），并预测其可能的靶基因。方法：我们在PubMed数据库（PROSPERO，CRD42017077742）上进行了系统综述，以了解c-miRNA和人类肥胖的原始著作，并记录具有差异表达谱的c-miRNA。使用生物信息学工具搜索了miRNA失调的潜在靶基因和代谢途径，至少有两个独立的报告。结果：与瘦对照组相比，肥胖患者中22个c-miRNA过度表达，9个表达不足和2个c-miRNA双向表达失调。生物信息学分析表明，这些c-miRNA靶向与脂肪酸代谢和PI3k / Akt途径相关的基因。结论：文献记录了33种证实在人类肥胖中失调的c-miRNA。他们的预测靶基因参与了可能解释肥胖症及其合并症发展的途径。进一步的研究将阐明这些miRNA在代谢疾病中的作用及其在肥胖的预后，预防和治疗中的作用。