Cross-modal sensory communication is an innate biological process that refers to the combination and/or interpretation of different types of sensory input in the brain. Often, this process conjugates with neural modulation, by which the neural signals that convey sensory information are adjusted, such as intensity, frequency, complexity, and/or novelty. Although the anatomic pathways involved in cross-modal sensory integration have been previously described, the course of development and the physiological roles of multisensory signaling integration in brain functions remain to be elucidated. In this article, I review some of the recent findings in sensory integration from research using the zebrafish models. In zebrafish, cross-modal sensory integration occurs between the olfactory and visual systems. It is mediated by the olfacto-retinal centrifugal (ORC) pathway, which originates from the terminalis nerve (TN) in the olfactory bulb and terminates in the neural retina. In the retina, the TNs synapse with the inner nuclear layer dopaminergic interplexiform cells (DA-IPCs). Through the ORC pathway, stimulation of the olfactory neurons alters the cellular activity of TNs and DA-IPCs, which in turn modulates retinal neural function and increases behavioral visual sensitivity.

中文翻译：

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感觉统合：斑马鱼嗅觉和视觉系统之间的跨模态交流。

跨模式的感觉交流是一种先天的生物学过程，是指大脑中不同类型的感觉输入的组合和/或解释。通常，该过程与神经调制相结合，通过神经调制，可以调节传达感觉信息的神经信号，例如强度，频率，复杂性和/或新颖性。尽管先前已经描述了涉及跨模态感觉统合的解剖学途径，但是仍需要阐明发展过程和多感觉信号统合在脑功能中的生理作用。在本文中，我回顾了使用斑马鱼模型进行的感官整合的一些最新发现。在斑马鱼中，嗅觉和视觉系统之间发生了跨模式的感觉整合。它是由嗅球视网膜离心（ORC）途径介导的，该途径起源于嗅球的终末神经（TN），并终止于神经视网膜。在视网膜中，TNs与内核层多巴胺能丛状细胞（DA-IPC）发生突触。通过ORC途径，刺激嗅觉神经元会改变TN和DA-IPC的细胞活性，进而调节视网膜神经功能并增加行为视觉敏感性。