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The multiple flavors of GoU pairs in RNA.
Journal of Molecular Recognition ( IF 2.7 ) Pub Date : 2019-04-29 , DOI: 10.1002/jmr.2782
Eric Westhof 1 , Marat Yusupov 2 , Gulnara Yusupova 2
Affiliation  

Wobble GU pairs (or GoU) occur frequently within double-stranded RNA helices interspersed within the standard G═C and A─U Watson-Crick pairs. However, other types of GoU pairs interacting on their Watson-Crick edges have been observed. The structural and functional roles of such alternative GoU pairs are surprisingly diverse and reflect the various pairings G and U can form by exploiting all the subtleties of their electronic configurations. Here, the structural characteristics of the GoU pairs are updated following the recent crystallographic structures of functional ribosomal complexes and the development in our understanding of ribosomal translation.

中文翻译:

RNA中的GoU对具有多种风味。

摆动GU对(或GoU)在散布在标准G═C和A─UWatson-Crick对中的双链RNA螺旋中频繁发生。然而,已经观察到其他类型的GoU对在其Watson-Crick边缘上相互作用。这种替代GoU对的结构和功能作用令人惊讶地多样,并反映了G和U通过利用其电子构型的所有精妙之处可以形成的各种配对。在这里,GoU对的结构特征随着功能核糖体复合物的最新晶体学结构以及我们对核糖体翻译的理解的发展而更新。
更新日期:2019-11-01
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